The chemical, known as 6-shogaol, is produced when ginger roots are dried or cooked. The researchers found that 6-shogaol is active against cancer stem cells at concentrations that are harmless to healthy cells. This is dramatically different from conventional chemotherapy, which has serious side effects largely because it kills healthy as well as cancerous cells.
Cells responsible for 90 percent of cancer death?Like other stem cells, cancer stem cells possess the ability to differentiate into various different cell types. In the case of cancer, stem cells differentiate into the various malignant cells that make up a tumor colony. Although they make up less than 1 percent of the cells in any given tumor, stem cells are impervious to nearly all known or experimental chemotherapy agents. These cells are also able to replicate indefinitely, and they are capable of splitting off from their originating colony to start new tumors elsewhere. They are key players in the process of metastasis, which is responsible for 90 percent of cancer-related deaths.
The persistence of cancer stem cells also explains why cancers can recur even after seemingly successful tumor eradication via chemotherapy, radiation or surgery.
"Cancer stem cells pose serious obstacle to cancer therapy as they can be responsible for poor prognosis and tumour relapse," the researchers wrote. "To add into the misery, very few chemotherapeutic compounds show promise to kill these cells."
Kills cancer cells on many frontsThe researchers found that 6-shogaol targets breast cancer stem cells along several different pathways, including reducing the expression of surface markers, altering the cell cycle to increase the rate of cell death, inhibiting tumor formation, directly inducing programmed cell death, and flat-out poisoning cancer stem cells (cytotoxicity).
The researchers then compared the cytotoxicity of 6-shogaol against human breast cancer stem cells with that of the widely used chemotherapy drug taxol. They found that while taxol did show cytotoxicity in a one-dimensional laboratory model of cancer ("monolayer"), it showed almost no effect in the three-dimensional ("spheroid") model that is now believed to be a more accurate model of real-world cancer tumors. 6-shogaol, however, was effective in both the monolayer and spheroid models.
The researchers then increased the taxol concentration by 10,000 times, but it still showed no effectiveness in spheroid model.
"[T]axol, even though was highly active in monolayer cells, did not show activity against the spheroids even at 10,000 fold higher concentration compared to 6-shogaol," the researchers wrote.
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