A deadly strain of a hospital
superbug has become resistant to a last-line antibiotic used to treat
infections, scientists have warned. Although
it has not spread so far, doctors said 'the risk that MRSA could
eventually overwhelm even our last-line drugs is a very serious one'
branding it 'a dangerous organism in hospitals.' American researchers have found since 2002 there have been 12 cases of the antibiotic resistant superbug CC5.
A deadly cluster of MRSA bacteria. A type called CC5 has become proficient at picking up resistance gene
It
has become proficient at picking up resistance genes including the one
that makes it resistant to vancomycin - the last line of defence for
hospital-acquired infections.
Researcher
Jim Sliwa said: 'MRSA strains are leading causes of hospital-acquired
infections in the United States, and clonal cluster 5 (CC5) is the
predominant lineage responsible for these infections.
'Since 2002, there have been 12 cases of vancomycin-resistant S. aureus (VRSA) infection in the United States - all CC5 strains.'Vancomycin is a key last-line bactericidal drug for treating these infections.'
In
the study researchers sequenced the genomes of all available
vancomycin-resistant MRSA strains to find what distinguishes them from
other lineages and why CC5 is apparently more adept than other strains
at picking up vancomycin resistance.
Vancomycin-resistant
MRSA strains and other CC5 lineages have some important differences
from other types of MRSA, including adaptations that allow them to
co-exist with other types of bacteria and may help them take up foreign
DNA.It was found they lacked a set of genes that encode an antibiotic protein made by bacteria to kill other bacteria. Mr Sliwa said: 'This is important because it enables CC5 to get along well with other bacteria in mixed infections.
'Instead
of killing off competing organisms, CC5 aims to co-exist. This enables
it to pick up genes - like the one that encodes vancomycin resistance -
from unexpected places. 'Mixed
infections are breeding grounds for antibiotic resistance because they
encourage the exchange of genes among very different kinds of organisms.'In
roughly the place where these bacteriocin genes are missing is a unique
cluster of genes that encode enterotoxins - proteins that attack the
human host and, again, could make it easier for mixed populations of
bacteria to grow at infection sites.' Researchers also discovered CC5 has a mutation in a gene which is known to influence the ability to assimilate foreign DNA. He added: 'This makes CC5 a dangerous organism in hospitals.
'In
hospitals, pathogens are under continuous pressure from antibiotics to
survive and evolve, and CC5 isolates appear to be very well adapted to
succeed by acquiring new resistances. 'Frequent
use of antibiotics in hospital patients could select for strains like
CC5 that have an enhanced ability to co-exist with bacteria that provide
genes for antibiotic resistance.'The findings are published by the American Society for Microbiology.
Source: http://www.dailymail.co.uk/health/article-2147653/Deadly-strain-MRSA-resistant-line-antibiotic-used-treat-infections.html#ixzz1vvZLhqCe